Endoglin (CD105, ENG, END)

Referencia 029463-100ul

embalaje : 100ul

Marca : US Biological

Contact local distributor :


Teléfono : +1 850 650 7790


Host
mouse

Isotype
IgG1,k

Clone Number
44G4

Grade
Affinity Purified

Applications
FC IHC IP

Shipping Temp
Blue Ice

Storage Temp
-20°C

Endoglin (CD105) is a homodimeric integral membrane glycoprotein comprised of a 95kD subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-B) family of ligands to signaling receptors. Endoglin binds to TGF-B1 and TGF-B3 with high affinity, but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. Endoglin is also expressed by U937 cells and by activated macrophages. Endoglin expression is up-regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:200
Optimal dilutions to be determined by the researcher.

Positive Control:
HUVEC cells

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Type
Mab

Isotype
IgG1,k

Clone No
44G4

Host
mouse

Source
human

Concentration
As Reported

Form
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

Purity
Purified by Protein G affinity chromatography.

Immunogen
Whole HOON Pre-B Leukemic cells.

Specificity
Recognizes human CD105.


Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.