Endoglin (CD105, ENG, END)
Referencia 029463-100ul
embalaje : 100ul
Marca : US Biological
Host
mouseIsotype
IgG1,kClone Number
44G4Grade
Affinity PurifiedApplications
FC IHC IPShipping Temp
Blue IceStorage Temp
-20°CEndoglin (CD105) is a homodimeric integral membrane glycoprotein comprised of a 95kD subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-B) family of ligands to signaling receptors. Endoglin binds to TGF-B1 and TGF-B3 with high affinity, but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. Endoglin is also expressed by U937 cells and by activated macrophages. Endoglin expression is up-regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.
Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 1:200
Optimal dilutions to be determined by the researcher.
Optimal dilutions to be determined by the researcher.
Positive Control:
HUVEC cells
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Product Type
Mab
Isotype
IgG1,k
Clone No
44G4
Host
mouse
Source
human
Concentration
As Reported
Form
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Immunogen
Whole HOON Pre-B Leukemic cells.
Specificity
Recognizes human CD105.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.