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Pulegone [89-82-7]

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Referencia NB-64-46285-1g

embalaje : 1g

Marca : Neo Biotech

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Pulegone (Synonyms: (+)-Pulegone)

Catalog No. TCS0102 Copy Product Info

1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels. 3. Pulegone has negative reinforcing properties and seems to possess anxiolytic-like actions unrelated to the benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptor.

Pulegone

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Synonyms (+)-Pulegone

Cas No. 89-82-7

Batch Information

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Appearance:Liquid

Color:Transparent

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COA HNMR GC

Product Introduction

Pulegone AI Summary

Pulegone has demonstrated significant nematicidal and insecticidal activities in various biological assays. It is effective against Meloidogyne javanica and Meloidogyne incognita J2 (root-knot nematodes) larvae, reducing larval motility with EC50 values ranging from 0.205 µL/mL to 150.0 µg/mL. Additionally, it exhibits strong insecticidal activity against Frankliniella occidentalis (western flower thrips), achieving 100% mortality at a concentration of 1 µL/45 mL, and against Sitophilus granarius (granary weevil) with a 90% mortality rate. Moreover, Pulegone is toxic to Musca domestica (house fly), causing mortality with an LD50 of 92.2 µg after 24 hours and showing activity in displacing [3H]TBOB binding to the GABA receptor in Musca domestica head homogenates by 132% at 500 µM concentration after 90 minutes of incubation. The compound also influences various physiological and biochemical parameters in the body, such as chloride levels, albumin, liver enzymes (ALT, AST, ALP, LDH), blood urea nitrogen (BUN), glucose, lipid profile (cholesterol, triglycerides), electrolytes (sodium, potassium), blood cell counts (RBC, WBC), and differential white blood cell counts (lymphocytes, eosinophils, neutrophils, monocytes, basophils). It affects hemoglobin levels, hematocrit, platelet count, and mean cell volume, suggesting potential impacts on multiple physiological systems and processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

(+)-Pulegone

Chemical Properties

Molecular Weight	152.23
Formula	C₁₀H₁₆O
Cas No.	89-82-7
Smiles	C[C@@H]1CCC(=C(C)C)C(=O)C1
Relative Density.	0.937 g/mL at 25°C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (1313.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (16.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5690 mL	32.8450 mL	65.6901 mL	328.4504 mL
5 mM	1.3138 mL	6.5690 mL	13.1380 mL	65.6901 mL
10 mM	0.6569 mL	3.2845 mL	6.5690 mL	32.8450 mL
20 mM	0.3285 mL	1.6423 mL	3.2845 mL	16.4225 mL
50 mM	0.1314 mL	0.6569 mL	1.3138 mL	6.5690 mL
100 mM	0.0657 mL	0.3285 mL	0.6569 mL	3.2845 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.