LYVE1 (XLKD1) Antibody (C-term)

Referencia AP2015b

embalaje : 400ul

Marca : Abcepta

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Teléfono : +1 850 650 7790

  • WB - LYVE1 (XLKD1) Antibody (C-term) AP2015b
    XLKD1 Antibody (C-term) (Cat. #AP2015b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the XLKD1 antibody detected the XLKD1 protein (arrow).
  • IHC-P - LYVE1 (XLKD1) Antibody (C-term) AP2015b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9Y5Y7
Other Accession Q6UC88, NP_006682
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 35213 Da
Antigen Region 243-272 aa
Additional Information
Gene ID 10894
Other Names Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, LYVE1, CRSBP1, HAR, XLKD1
Target/Specificity This LYVE1 (XLKD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human LYVE1 (XLKD1).
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLYVE1 (XLKD1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LYVE1
Synonyms CRSBP1, HAR, XLKD1
Function Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460).
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans- Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface Localizes at cell-cell junctions
Tissue Location Mainly expressed in endothelial cells lining lymphatic vessels.

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Referencia
Descripción
Cond.
Precio Sin IVA
CHE0019-096
 96wells 
AP2015b-ev
 80ul