NCC antibody

Referencia orb152704-100ug

embalaje : 100ug

Marca : Biorbyt

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NCC antibody

NCC antibody

Catalog Number: orb152704

Catalog Numberorb152704
CategoryAntibodies
DescriptionRabbit polyclonal to NCC (PerCP). NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis. Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC. Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension. Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat..
Species/HostRabbit
ClonalityPolyclonal
Tested applicationsICC, IEM, IHC, WB
ReactivityCanine, Human, Mouse, Rat
ImmunogenProduced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
Concentration1 mg/ml
Dilution rangeWB (1:1000), IHC (1:200)
ConjugationPerCP
MW160kDa
TargetNCC
Entrez6559, 54300
UniProt IDP55017, P55018
NCBI6559, 54300, NP_000330, NP_062218
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Alternative namesSLC12A3 antibody, SCYL1 antibody,CKb10 antibody, M
NoteFor research use only
Application notes1 µg/ml of SPC-402 was sufficient for detection of NCC3 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Expiration Date12 months from date of receipt.