Specifications

Product Data
Applications	IHC
Recommended Dilution	IHC: 25-100 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 195-212 amino acids of Human Keratin, type I cytoskeletal 10
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Gene Name	keratin 10
Database Link	NP_000412 Entrez Gene 16661 MouseEntrez Gene 450225 RatEntrez Gene 3858 Human UniProt ID P13645
Background	This gene encodes a member of the type I (acidic) cytokeratin family; which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments; along with actin microfilaments and microtubules; compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
Synonyms	BCIE; BIE; CK10; EHK; K10; KPP
Reference Data