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Carvacrol [499-75-2]

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Referencia T4S1990-100mg

embalaje : 100mg

Marca : TargetMol

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Carvacrol (Synonyms: O-Thymol, Karvakrol, cymophenol)

Carvacrol

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Synonyms O-Thymol, Karvakrol, cymophenol

Cas No. 499-75-2

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.05%

Appearance:Liquid

Color:Transparent

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COA LCMS HNMR

Product Introduction

Carvacrol AI Summary

Carvacrol exhibits a wide range of bioactivities across different biological systems. It has hypnotic activity (HD50 = 30.0 mg/kg) and acute toxicity (LD50 = 80.0 mg/kg) in mice. It binds to human UDP Glucuronosyltransferase 1A4 (Km = 1500000.0 nM), inhibits COX1 (IC50 = 4000.0 nM), and shows agonist activity at the human TRPA1 channel (EC50 = 7000.0 nM). It is also involved in various UDP-glucuronosyltransferase isoforms, indicating roles in drug metabolism and detoxification. Additionally, it exhibits insecticidal (LD50 = 33.3 µg), antifungal, and antibacterial activities with varying MIC and IC50 values. It affects voltage-gated sodium channels in rat DRG neurons, displays repellent activity against Tribolium castaneum, and nematicidal activity against Meloidogyne species (EC50 = 0.128 µL/mL to 264.0 µg/mL). It modulates nerve excitability and inhibits Cav1.2 calcium current (IC50 = 98000.0 nM). Carvacrol inhibits enzymes like AChE and BuChE with IC50 values of 288260.0 nM and 410790.0 nM, respectively. It shows toxicity to Musca domestica, antioxidant activity (IC50 = 131.24 µg/mL), anticonvulsant, and neurotoxic effects, and inhibits Mycobacterium tuberculosis chorismate mutase (IC50 = 1060.0 nM). It also displays bioactivity against SARS-CoV-2 by inhibiting cytotoxicity in VERO-6 cells and the SARS-CoV-2 3CL-Pro protease (21.29% inhibition at 20 µM). Carvacrol has a logP value of 3.49, indicating its lipophilicity, and potential as a modulator in various pharmacological contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems.
Synonyms	O-Thymol, Karvakrol, cymophenol

Chemical Properties

Molecular Weight	150.22
Formula	C₁₀H₁₄O
Cas No.	499-75-2
Smiles	CC(C)c1ccc(C)c(O)c1
Relative Density.	0.97

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1664.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6569 mL	33.2845 mL	66.5690 mL	332.8452 mL
5 mM	1.3314 mL	6.6569 mL	13.3138 mL	66.5690 mL
10 mM	0.6657 mL	3.3285 mL	6.6569 mL	33.2845 mL
20 mM	0.3328 mL	1.6642 mL	3.3285 mL	16.6423 mL
50 mM	0.1331 mL	0.6657 mL	1.3314 mL	6.6569 mL
100 mM	0.0666 mL	0.3328 mL	0.6657 mL	3.3285 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.