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Human monomers - Class II

Human monomers - Class II


T lymphocytes play a central role in immune system function.
Monomeric MHC/peptide complexes proved to be impractical due to their instability and low affinity yo TCRs. To overcome this difficulty, MHC/peptide monomers are biotinylated and tetramerized with streptavidin to maintain stable binding to multiple TCRs, enabling MHC/peptide tetramers to be used as detection tools.
Biotinylated MHC monomers, the building blocks of MHC tetramers, are now available for tetramer construction flexibility and novel applications.
The Biotinylated Class II MHC/peptide complex can be used in research studies involving CD4+ antigen-specific T cells




Biotinylated MHC class II monomer is composed of a particular peptide in combination with a particular HLA class II allele that has been biotinylated at the c-terminus of the beta chain extracellular domain.

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