Bladder cancer - New quadruple color FISH probe
NEW - 2 HOURS HYBRIDIZATION PROTOCOL
Only one probe for the detection of CDKN2A deletions and aneuploidy of chromosomes 3, 7, and 17
The ZytoLight® Bladder Cancer Quadruple Color Probe is designed to detect CDKN2A (a.k.a. p16) deletions and aneuploidy of chromosomes 3, 7, and 17 in cytology specimens of tumors, e.g., in urine samples from patients with hematuria suspected of having bladder cancer (BC). Homozygous deletion of the CDKN2A gene at 9p21.3 and polysomy of chromosome 3, 7, and/ or 17 are common abnormalities observed in urothelial cell carcinoma, all of which can be detected by FISH. Moreover, it has been shown that the detection of CDKN2A deletions and/or aneusomies of chromosomes 3, 7, and/ or 17 may be used for the surveillance of patients with a history of bladder cancer to early detect possible tumor recurrence.
FISH on cells from urine has been shown to be highly sensitive and specific for detection of tumor cells. It can detect recurrence earlier than other methods like cytology, cystoscopy, or biopsy histological examination.
Urothelial cell line with polysomy of chromosomes
3, 7, and 17 as indicated by 3-4 red, green,
and blue signals in each nucleus
The ZytoLight® Bladder Cancer Quadruple Color Probe is available in 2 formats :
5 tests (50µl)
20 tests (200µl)
The corresponding Implementation Kit contain all necessary reagents to perform successful FISH experiments:
Medical devices for in vitro diagnosis. Read the operating instructions carefully.