Reactivos e instrumentos para inmunología, biología celular y biología molecular.

NDMC101 [1308631-40-4]

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Referencia NB-64-44873-1mL

embalaje : 1mLx10mM(inDMSO)

Marca : Neo Biotech

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NDMC101

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Synonyms:

Catalog No. T8550 Copy Product Info

Purity: 99.89%

NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.

Cas No. 1308631-40-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Appearance:Solid

Color:White

Product Information

Bioactivity

Description	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
In vitro	NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts[1].
In vivo	In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion.?Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg[1].
Cell Research	Differentiation into osteoclast-like cells was examined by tartrate-resistant acid phosphatase (TRAP) staining and expression of osteoclast differentiation markers[1].
Animal Research	Collagen-induced arthritis (CIA) mice were administered test articles by gavages to assess its efficacy.?Then clinical, histological, and biochemical parameters were assessed to determine the effects of N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide (NDMC101) on synovial inflammation and bone erosion by hematoxlin and eosin staining and Enzyme-linked immunosorbent assay (ELISA)[1].

Chemical Properties

Molecular Weight	265.67
Formula	C₁₃H₉ClFNO₂
Cas No.	1308631-40-4
Smiles	Oc1ccccc1C(=O)Nc1ccc(Cl)cc1F
Relative Density.	1.452 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (41.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7641 mL	18.8203 mL	37.6407 mL	188.2034 mL
5 mM	0.7528 mL	3.7641 mL	7.5281 mL	37.6407 mL
10 mM	0.3764 mL	1.8820 mL	3.7641 mL	18.8203 mL
20 mM	0.1882 mL	0.9410 mL	1.8820 mL	9.4102 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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