Ankyrin-2 or -Ankyrin-B is encoded by the gene ANK2. Ankyrin B is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin B is expressed in brain and muscle. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N105/17
IgG2a
ELISA, ICC, IHC, IP, WB
Mouse
ANK2 ANKB
<200 kDa
Fusion protein amino acids 203-496 of human Ankyrin-B (accession number Q01484) produced recombinantly in E. Coli
Human
C. elegans, Guinea Pig, Human, Mouse, Rat
AB_10673095
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.71
WB: 1:1000 IHC: 1:200 ICC: 1:200
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
![Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N105/17 (left) or N52A/42 (right) TC supe.](/proxy_img/Ly93d3cuYW50aWJvZGllc2luYy5jb20vY2RuL3Nob3AvcHJvZHVjdHMvdmFsaWRhdGlvbi1pbWFnZS03My0xNDUtbjEwNS0xNy13YjJfZTQ1ODA4M2YtYThlMS00NmQzLWI2OTMtN2FiMDFjZjA5OWRkXzEyMHgxMjAuanBnP3Y9MTYyNjkwMzUxMQ==.jpg?v=1626903511)
![Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N105/17 (left) or N52A/42 (right) TC supe.](/proxy_img/Ly93d3cuYW50aWJvZGllc2luYy5jb20vY2RuL3Nob3AvcHJvZHVjdHMvdmFsaWRhdGlvbi1pbWFnZS03My0xNDUtbjEwNS0xNy13YjJfZTQ1ODA4M2YtYThlMS00NmQzLWI2OTMtN2FiMDFjZjA5OWRkXzgwMHguanBnP3Y9MTYyNjkwMzUxMQ==.jpg?v=1626903511)
