CASPR (Neurexin IV) is part of the neurexin family, which includes presynaptic proteins located in the presynaptic membrane of the brain.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
K65/35
IgG1
ELISA, ICC, IHC, IP, WB
Mouse
Cntnap1 Caspr Nrxn4
220 kDa
Fusion protein 1308-1381 (cytoplasmic domain) of rat Caspr (accession number P97846) produced recombinantly in E. Coli
Rat
Gerbil, Human, Mouse, Rat
AB_2083496
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000 IHC: 1:250 ICC: 1:500
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190)
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].](/proxy_img/Ly93d3cuYW50aWJvZGllc2luYy5jb20vY2RuL3Nob3AvZmlsZXMvNzUtMDAxLWs2NS0zNS13Yi0zXzEyMHgxMjAuanBnP3Y9MTcwMjMxODg4MQ==.jpg?v=1702318881)
![EGFP expression (green) was absent in the optic nerves of [gfap] dnVAMP2 mice supplied DOX (DOX-ON) and prevalent in astrocytes in the optic nerves of [gfap] dnVAMP2 mice on a diet without DOX (DOX-OFF) from gestation through adulthood (P70). EGFP expression in astrocytes was also elevated for a DOX-ON diet through development with DOX_OFF for P40 to P70 (30 d DOX-OFF). The paranodal region labeled with Caspr1 (red). DNA labelled with DAPI (blue). Image from publication CC-BY-4.0. PMID:36302632](/proxy_img/Ly93d3cuYW50aWJvZGllc2luYy5jb20vY2RuL3Nob3AvcHJvZHVjdHMvNzUtMDAxLWs2NS0zNS1paGMtM18xMjB4MTIwLmpwZz92PTE3MDIzMTg4ODE=.jpg?v=1702318881)
