General Info
| Host: | Mouse |
| Applications: | FC/WB/IF/IHC |
| Reactivity: | Horse/Human/Monkey/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Proximal Nephrogenic Renal antigen (CD205) is suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | PN-15 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunoblotting (1-2 µg/ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (formalin-fixed: 2-4 µg/ml for 30 min at RT; staining of formalin-fixed tissues requires boiling tissue sections |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
Information
| Gene Symbol: | LY75 |
| Gene ID: | 100526664/4065 |
| Uniprot ID: | LY75_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with renal cortical tissue extract.Fusion partner: Sp2/0. |
Description
| Tissue Specificity | Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B-lymphocytes. |
| Protein Name | Lymphocyte Antigen 75Ly-75C-Type Lectin Domain Family 13 Member BDec-205Gp200-Mr6Cd Antigen Cd205 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Lymphocyte Antigen 75 antibodyAnti-Ly-75 antibodyAnti-C-Type Lectin Domain Family 13 Member B antibodyAnti-Dec-205 antibodyAnti-Gp200-Mr6 antibodyAnti-Cd Antigen Cd205 antibodyAnti-LY75 antibodyAnti-CD205 antibodyAnti-CLEC13B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance