General Information
| Short Description | Rabbit polyclonal anti-Bax inhibitor 1 (93-143) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen | Synthesized peptide derived from human BI1 AA range: 93-143 |
| Immunogen Region | 93-143 |
| Specificity | This antibody detects endogenous levels of human BI1 |
Additional Info
| Post Translational Modifications | Ubiquitinated by BFAR, leading to proteasomal degradation. |
| Function | Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation. |
| Protein Name | Bax Inhibitor 1Bi-1Testis-Enhanced Gene Transcript ProteinTransmembrane Bax Inhibitor Motif-Containing Protein 6 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Bax Inhibitor 1 antibodyAnti-Bi-1 antibodyAnti-Testis-Enhanced Gene Transcript Protein antibodyAnti-Transmembrane Bax Inhibitor Motif-Containing Protein 6 antibodyAnti-TMBIM6 antibodyAnti-BI1 antibodyAnti-TEGT antibody |
Information sourced from Uniprot.org