Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Aucubin [479-98-1]

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Cat# T3416-5mg

Size : 5mg

Marca : TargetMol

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Aucubin

(Synonyms: Rhinanthin, Aucuboside) Copy Product Info

Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Cas No. 479-98-1

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.83%

Color:White

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COA

Product Introduction

Aucubin AI Summary

Aucubin exhibits a range of bioactivities, including inhibiting the classical complement pathway activation at 4 µM with significantly higher inhibition (89.3%) in the presence of beta glucosidase. It demonstrates potent inhibition of L3MBTL1 (63.1 nM) and induces DNA re-replication (183.6 nM) in SW480 colon adenocarcinoma cells. The compound also shows estrogenic activity at the ERalpha in human MVLN cells with activities of 81.25% and 99.1% at concentrations of 100 µg/mL and 20 µg/mL, respectively, compared to E2. It inhibits electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at 2 mg/mL, although the inhibition percentages are modest (-1.28% for AChE and -12.67% for BChE). Additionally, it exhibits moderate to high inhibitory activity against the COX1 enzyme (48.2% to 50.2%) but weaker activity against the COX2 enzyme (below 30%). It shows no significant cytotoxicity against various human cancer cell lines (IC50 > 10000 nM) and demonstrates minimal inhibitory effects against SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM). Lastly, it exhibits 0.14% inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Synonyms	Rhinanthin, Aucuboside

Chemical Properties

Molecular Weight	346.33
Formula	C₁₅H₂₂O₉
Cas No.	479-98-1
Smiles	OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O
Relative Density.	1.61 g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (288.74 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8874 mL	14.4371 mL	28.8742 mL	144.3710 mL
5 mM	0.5775 mL	2.8874 mL	5.7748 mL	28.8742 mL
10 mM	0.2887 mL	1.4437 mL	2.8874 mL	14.4371 mL
20 mM	0.1444 mL	0.7219 mL	1.4437 mL	7.2185 mL
50 mM	0.0577 mL	0.2887 mL	0.5775 mL	2.8874 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4437 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.