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Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Azithromycin [83905-01-5]

Stampa

Cat# B1398-50mg

Size : 50mg

Contatta il distributore locale :

Telefono : +1 850 650 7790

Marca : ApexBio Technology

Contatta il distributore locale :

Telefono : +1 850 650 7790

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Background

Azithromycin is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.

Product Citation

1. Ng MY, Zhang H, et al. "New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery." ACS Med Chem Lett. 2018 Nov 21;9(12):1285-1291. PMID:30613341
2. Martin Y Ng, Haibo Zhang, et al. "A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery." bioRxiv. 2018 May 24.

Chemical Properties

Storage	Store at -20°C
M.Wt	748.98
Cas No.	83905-01-5
Formula	C38H72N2O12
Solubility	≥75.05 mg/mL in DMSO; insoluble in H2O; ≥102.8 mg/mL in EtOH
SDF	Download SDF
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Trypanocidal activity experiment [1]:
Trypanosomes	T. congolense, T. b. brucei and T. evansi
Preparation method	The solubility of this compound in DMSO is > 30.1 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.
Reacting condition	0.32 ~ 25 μM; 72 hrs
Applications	The IC50 values of Azithromycin for T. congolense, T. b. brucei and T. evansi were 0.19 ± 0.17, 3.69 ± 2.26 and 1.81 ± 1.82 μM, respectively.
Animal experiment [1]:
Animal models	Mice infected with T. congolense
Dosage form	50, 100, 200, 300 and 400 mg/kg; p.o.
Applications	In mice infected with T. congolense, Azithromycin dose-dependently killed T. congolense, with the initial clearance of the parasites from the peripheral circulation in all treatment groups. However, this was followed by a relapse resulting in the rapid growth of the parasites. On the other hand, the survival rate was significantly prolonged in all treatment groups. A number of mice survived in the 200, 300 and 400 mg/kg Azithromycin groups, while all mice in the control and the 50 and 100 mg/kg Azithromycin groups died.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Molefe NI, Yamasaki S, Macalanda AMC, Suganuma K, Watanabe K, Xuan X, Inoue N. Oral administration of azithromycin ameliorates trypanosomosis in Trypanosoma congolense-infected mice. Parasitol Res. 2017 Jul 4.

Quality Control

Purity = 98.00%

Chemical structure

Azithromycin

Related Biological Data

Azithromycin

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