CA IX (H-11)
Cat# sc-365900
Size : 200µg/ml
Marca : Santa Cruz Biotechnology
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Anticorps CA IX (H-11): sc-365900
- L'anticorps CA IX H-11 est un monoclonal IgG2a κ L'Anticorps CA IX, cité dans 23 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 41-160 de CA IX d'origine human
- L'Anticorps CA IX (H-11) est recommandé pour la détection de CA IX d'origine human par WB, IP, IF, IHC(P) et ELISA
- Anti-L'Anticorps CA IX (H-11) est disponible conjugué à l'agarose pour IP; à l'HRP pour WB, IHC(P) et ELISA; et soit à la phycoerythrin ou FITC pour IF, IHC(P) et FCM
- aussi disponible conjugué à l'Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 pour WB (RGB), IF, IHC(P) et FCM
- aussi disponible conjugué à l'Alexa Fluor® 680 ou Alexa Fluor® 790 pour WB (NIR), IF et FCM
- également disponible conjugué à la biotine pour WB, IHC(P) et ELISA
- m-IgG Fc BP-HRP et m-IgGκ BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps CA IX (H-11) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps CA IX (H-11) ().
ACCÈS RAPIDE AUX LIENS
, CA II, CA III, CA IV, CA IX, CA V, CA VB, CA VI, CA VII et CA VIII
CA IX Antibody (H-11) is an IgG2a κ mouse monoclonal CA IX antibody (also designated CAIX antibody, Carbonic anhydrase IX antibody, carbonate dehydratase metalloenzyme antibody, zinc metalloenzyme antibody, cell membrane-associated carbonic anhydrase 9 antibody, transmembrane dimeric zinc metalloenzyme antibody, or gastrointestinal tract carbonic anhydrase antibody) that detects the CA IX protein of human origin by WB, IP, IF, IHC(P) and ELISA. CA IX Antibody (H-11) is available as both the non-conjugated anti-CA IX antibody form, as well as multiple conjugated forms of anti-CA IX antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes including respiration, calcification, acid-base balance and bone resorption, as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric juice. They show extensive diversity in distribution and in their subcellular localization. The human CA2 gene, which maps to chromosome 8q21, encodes CA II, a cytoplasmic protein that has the highest turnover rate and widest tissue distribution of any known human CA isozyme. The human CA4 gene, which maps to chromosome 17q23, encodes CA IV, a membrane-anchored isozyme that is expressed on the luminal surfaces of pulmonary capillaries and proximal renal tubules. The human CA9, CA12 and CA14 genes, which map to chromosomes 9p13, 15q22 and 1q21, respectively, encode transmembrane proteins that have unique patterns of tissue-specific expression. CA IX is specifically expressed in clear-cell renal carcinomas, whereas CA XII is highly expressed in normal tissues, such as kidney, colon and pancreas. Human CA XIV is also expressed in normal tissues, such as brain, but differs from CA XII in its expression pattern.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. | Fujikawa-Adachi, K., et al. 1999. Genomics. 61: 74-81. PMID: 10512682
- Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes. | Okuyama, T., et al. 1992. Proc Natl Acad Sci U S A. 89: 1315-9. PMID: 1311094
- Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His----Tyr): complete structure of the normal human CA II gene. | Venta, PJ., et al. 1991. Am J Hum Genet. 49: 1082-90. PMID: 1928091
- Human carbonic anhydrases and carbonic anhydrase deficiencies. | Sly, WS. and Hu, PY. 1995. Annu Rev Biochem. 64: 375-401. PMID: 7574487
- Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. | Ivanov, SV., et al. 1998. Proc Natl Acad Sci U S A. 95: 12596-601. PMID: 9770531
Espèces | Nom du Gène | Gene ID | Localisation chromosomique | Numéro d'accession de l'isoforme (ARNm) | Numéro d'accès aux protéines | Numéro OMIM™ |
---|---|---|---|---|---|---|
Human | CA9 | Entrez Gene ID: 768 | 9p13.3 | NM_001216 | UniProt ID: Q16790 | 603179 |
Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz® conjugates which eliminates the need for a secondary antibody.
Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CA IX Antibody (H-11) has 23 citations in a variety of scientific publications.
Primary antibodies like Anti-CA IX Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.
In your description, you write that H-11 was "raised against amino acids 41-160 of CA IX of human origin". Do you have a more precise binding epitope for this antibody?
Hi, Is this antibody suitable for flow cytometry?
What is the total volume provided of CA IX (H-11):sc-365900 monoclonal antibody?
Can CA IX (H-11): sc-365900 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
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