CALCOCO2 (Calcium Binding and Coiled Coil Domain 2, Calcium Binding and Coiled-coil Domain Containing Protein 2, Antigen Nuclear Dot 52kD Protein, MGC17318, Nuclear Domain 10 Protein 52, Nuclear Domain 10 Protein NDP52, Nuclear Domain Protein 52, Nuclear Dot Protein 52, NDP52)

CALCOCO2 is a subunit of nuclear domain 10 (ND10) bodies, which are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by herpes simplex virus-1 infection and may have a role in viral life cycles. CALCOCO2 is part of a complex along with TAX1BP1 and MYO6. It also interacts with GEMIN4 and may play a role in ruffle formation and actin cytoskeleton organization.

Suitable for use in Western Blot. Other applications not tested.

Optimal dilutions to be determined by the researcher.

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Mab

IgG1

2623C2_2a

mouse

human

~0.1mg/ml

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

Purified by Protein G affinity chromatography from hybridoma culture supernatant

Synthetic peptide corresponding to the middle region of human CALCOCO2

Recognizes human CALCOCO2.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.