CD80, CT (CD80, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, CD80) (APC)

Cat# MBS6283501-0,2mL

Size : 0.2mL

Marca : MyBiosource


CD80 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6283501

CD80 is activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells. More details

Product Overview

Online Datasheet in PDF
Product Name
CD80, Polyclonal Antibody
Full Product Name
CD80, CT (CD80, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, CD80) (APC)
Product Gene Name
anti-CD80 antibody
Product Synonym Names
CD80; CD28LG; CD28LG1; LAB7; T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; CD80
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human CD80.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
18,761 Da
OMIM
M27533 mRNA
3D Structure
ModBase 3D Structure for P33681
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 260-288 in the C-terminal region of human CD80, UniProt Accession #P33681.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CD80 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-CD80 antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-CD80 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CD80 antibody

Western Blot analysis in HL-60 cell line lysates (35ug/lane) using 033542. CD80 (arrow) was detected using the purified Pab.
Rabbit Anti-CD80 Polyclonal Antibody – Cat# MBS6283501

Flow Cytometry (FC/FACS) of anti-CD80 antibody

Flow Cytometry analysis of HL-60 cells using 033542 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CD80 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6283501

Product References and Citations for anti-CD80 antibody

1. Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010). 2. Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010). 3. Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009).

Other Notes

Small volumes of anti-CD80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD80 purchase

MBS6283501 is an antibody targeting CD80. Also known as CD80, CT (CD80, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, CD80) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD80. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-lymphocyte activation antigen CD80
NCBI Official Synonym Full Names
CD80 molecule
NCBI Official Symbol
CD80
NCBI Official Synonym Symbols
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
UniProt Protein Name
T-lymphocyte activation antigen CD80
UniProt Synonym Protein Names
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
Protein Family
T-lymphocyte activation antigen
UniProt Gene Name
CD80
UniProt Synonym Gene Names
CD28LG; CD28LG1; LAB7; B7
NCBI Protein Information
T-lymphocyte activation antigen CD80

NCBI Summary for CD80

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
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UniProt Comments for CD80

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD80 antibody

 Reference Product  PubMed Publications
 CD86 antibody  >4647 publications with CD80 and CD86
 CD4 antibody  >2101 publications with CD80 and CD4
 CD28 antibody  >1801 publications with CD80 and CD28
 CTLA4 antibody  >1008 publications with CD80 and CTLA4
 ICAM1 antibody  >414 publications with CD80 and ICAM1
 PRF1 antibody  >62 publications with CD80 and PRF1
 IFNG antibody  >6 publications with CD80 and IFNG
 CSF2 antibody  >2 publications with CD80 and CSF2

Pathways associated with anti-CD80 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram

Diseases associated with anti-CD80 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1099 publications with CD80 and Necrosis
 Inflammation Antibodies  >728 publications with CD80 and Inflammation
 Neoplasms, Experimental Antibodies  >376 publications with CD80 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >342 publications with CD80 and Nervous System Diseases
 Lung Diseases Antibodies  >301 publications with CD80 and Lung Diseases
 Liver Diseases Antibodies  >221 publications with CD80 and Liver Diseases
 Kidney Diseases Antibodies  >149 publications with CD80 and Kidney Diseases
 Lung Neoplasms Antibodies  >110 publications with CD80 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >81 publications with CD80 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >80 publications with CD80 and Breast Neoplasms

Organs/Tissues associated with anti-CD80 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5864 publications with CD80 and Blood
 Lymph Node Antibodies  >576 publications with CD80 and Lymph Node
 Lung Antibodies  >412 publications with CD80 and Lung
 Thymus Antibodies  >177 publications with CD80 and Thymus
 Tonsil Antibodies  >39 publications with CD80 and Tonsil
 Connective Tissue Antibodies  >33 publications with CD80 and Connective Tissue
 Mammary Gland Antibodies  >4 publications with CD80 and Mammary Gland