Chitobiose (dihydrochloride) [115350-24-8]

Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity^[1][2].

Chitobiose (100 μM; 24 h prior to LPS stimulation) dihydrochloride exhibits no anti-inflammatory activity in LPS (HY-D1056)-stimulated RAW264.7 cells, as it does not alter levels of IL-1β, IL-10, IL-17A, or IFN-γ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Qini Zhao, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020 Apr 11;2020:2394704.  [Content Brief]

  [2]. Chen AS, et al. Effect of chitobiose and chitotriose on carbon tetrachloride-induced acute hepatotoxicity in rats. Biol Pharm Bull. 2005;28(10):1971-1973.  [Content Brief]