EGTA [67-42-5]
Cat# T4585-2g
Size : 2g
Marca : TargetMol
EGTA
(Synonyms: Ethylenebis(oxyethylenenitrilo)tetraacet) Copy Product Info
Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Cas No. 67-42-5
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.92%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Information
EGTA AI Summary
EGTA exhibits multi-faceted biological activities. It significantly inhibits the invasion of Plasmodium falciparum FCB2 merozoites into human erythrocytes, showing an inhibition rate of 83.0% at a concentration of 50 mM and 90.0% at 1.9 mg/mL after 18 hours. Additionally, it demonstrates a substantial inhibition of aph8 phosphorylation in Streptomyces coelicolor cell lysate, achieving a 94.0% inhibition as assessed by [32Pi] incorporation. Moreover, compound 405836 is involved in inhibiting various enzymes and biological processes, including APE1, fructose-1,6-bisphosphate aldolase, Bloom's syndrome helicase BLM, HADH2, and histone lysine methyltransferase G9a. It also modulates PMP22 expression/activity, acts as an allosteric agonist for the human D1 dopamine receptor, and inhibits cell entry of Lassa and Marburg viruses. Additionally, it enhances Arylsulfatase A and activates the ryanodine receptor in Spodoptera litura muscle membrane, inducing a Ca2+ pump activity at 0.8 mM after 30 minutes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively. |
| Synonyms | Ethylenebis(oxyethylenenitrilo)tetraacet |
| Molecular Weight | 380.35 |
| Formula | C14H24N2O10 |
| Cas No. | 67-42-5 |
| Smiles | OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O |
| Relative Density. | 1.433 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | 0.1 M NaOH: 25 mg/mL (65.73 mM), Sonication is recommended.  DMSO: Insoluble H2O: < 1 mg/mL (insoluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
0.1 M NaOH
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
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Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
macrophagesirrigantionInhibitorinhibitinflammatoryendodonticEGTAchelatorcalcium
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Related Tags: EGTA chemical structure | EGTA formula | EGTA molecular weight
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