Biological Activity

Estradiol (17β-estradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (17β-estradiol) can be used to construct animal models of chronic non-bacterial prostatitis.

Product Citations

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  Int Immunopharmacol. 2026 Mar 06;175:116471.

  CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis.
  Estradiol purchased from AbMole

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  Biol Sex Differ. 2025 Dec 23;16:107.

  The mechanism study of targeting DPP4 in regulating ferroptosis and its influence on endometrial receptivity in PCOS.
  Estradiol purchased from AbMole

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  Fertil Steril. 2023 May 12;S0015-0282(23)00241-8.

  Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis
  Estradiol purchased from AbMole

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  Molecules. 2023 Apr 7.

  Study of the Sensing Kinetics of G Protein-Coupled Estrogen Receptor Sensors for Common Estrogens and Estrogen Analogs
  Estradiol purchased from AbMole

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  Front Endocrinol (Lausanne). 2022 May 31;13:862789.

  TMPRSS2 Expression and Activity Modulation by Sex-Related Hormones in Lung Calu-3 Cells: Impact on Gender-Specific SARS-CoV-2 Infection
  Estradiol purchased from AbMole

Chemical Information

Molecular Weight	272.38
Formula	C18H24O2
CAS Number	50-28-2
Solubility (25°C)	DMSO 50 mg/mL Ethanol 20 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Amarylis Velez-Perez, et al. eNeuro. Estradiol Increases Microglial Response to Lipopolysaccharide in the Ventromedial Hypothalamus during the Peripubertal Sensitive Period in Female Mice

[2] Madsen CA, et al. Anim Reprod Sci. Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows.

[3] E Ingberg, et al. Gen Comp Endocrinol. Methods for long-term 17β-estradiol administration to mice