Our FOXO1/PAX7 fusion probe is designed to detect FOXO1/PAX7 fusions. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: FOXO1-PAX7 fusion is a cytogenetic hallmark of rhabdomyosarcoma (RMS). RMS is the most common soft tissue sarcoma in children and young adults, making up about 8% of all pediatric cancers. Histologically, RMS falls into two major subtypes: the more common embryonal rhabdomyosarcoma (ERMS) and the rarer but more aggressive alveolar rhabdomyosarcoma (ARMS). ARMS is characterized by a balanced chromosomal translocation t(1;13) (p36;q14), resulting in the FOXO1-PAX7 fusion, which is found in about 80% of ARMS and not in other sarcomas. Pediatric patients with fusion-positive (involving either PAX3 or PAX7) ARMS have shorter overall survival than those with fusion-negative ARMS.
Source: Kubo T, et al. (2015) Critical rev in onc/hemo 96.1:46-53.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: FOXO1
Gene Name: Forkhead Box O1
Chromosome: CHR13: 41129800-41240734
Locus: 13q14.11