Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare
 
> Gastrazole [862583-15-1]

Gastrazole [862583-15-1]

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Cat# HY-19445

Size : Onrequest

Marca : MedChemExpress


Description

Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreatic cancer[1][2].

IC50 & Target

CCKBR

 

In Vivo

Gastrazole (0.15-3 μmol/kg; i.v.) dose-dependently inhibits the Pentagastrin-stimulated gastric acid secretion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats with a gastric fistula[2]
Dosage: 0.15, 0.3, 3 mg/kg
Administration: Intravenous administration
Result: Dose-dependently inhibited Pentagastrin-stimulation acid secretion by maximally 73%.
Masse moléculaire

687.63

Formule

C34H32FN5Na2O7
CAS No.
SMILES

O=C(C(C=C(NC=N1)C1=C2)=C2C(NCC3CCCCCC3)=O)N[C@H](C(NC4=CC(C(O[Na])=O)=CC(C(O[Na])=O)=C4)=O)CC(C=CC=C5)=C5F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références