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> Glimepiride [93479-97-1]

Glimepiride [93479-97-1]

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Cat# T0127-200mg

Size : 200mg

Marca : TargetMol


Glimepiride

(Synonyms: HOE-490, Glimperide) Copy Product Info
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
Glimepiride
Cas No. 93479-97-1
Other Forms of Glimepiride:
Glimepiride (Standard)
Glimepiride-D8
Glimepiride-D4-1
Glimepiride-D5
For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:98.87%
Color:White

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COA LCMS HNMR

Product Information

Bioactivity
Description
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
Targets & IC50
SUR1:3 nM, SUR2B:7.3 nM, SUR2A:5.4 nM
In vitro
In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits.
In vivo
Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity.
SynonymsHOE-490, Glimperide
Chemical Properties
Molecular Weight490.62
FormulaC24H34N4O5S
Cas No.93479-97-1
SmilesC(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](C)CC2)=O)(=O)=O)C=C1)(=O)N3C(=O)C(CC)=C(C)C3
Relative Density.1.29 g/cm3
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (61.15 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 1.5 mg/mL (3.06 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0382 mL10.1912 mL20.3824 mL101.9119 mL
5 mM0.4076 mL2.0382 mL4.0765 mL20.3824 mL
10 mM0.2038 mL1.0191 mL2.0382 mL10.1912 mL
20 mM0.1019 mL0.5096 mL1.0191 mL5.0956 mL
50 mM0.0408 mL0.2038 mL0.4076 mL2.0382 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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Keywords

SUR2BSUR2ASUR1PotassiumChannelPotassium ChannelInhibitorinhibitHOE490HOE 490Glimepiride
Related Tags: Glimepiride chemical structure | Glimepiride in vivo | Glimepiride in vitro | Glimepiride formula | Glimepiride molecular weight