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> Glycylsarcosine [29816-01-1]

Glycylsarcosine [29816-01-1]

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Cat# NB-64-45269-1g

Size : 1g

Marca : Neo Biotech


Glycylsarcosine (Synonyms: GLYCYL-SARCOSINE)

Catalog No. T8915 Copy Product Info
Purity: 98.47%
Glycylsarcosine (GLYCYL-SARCOSINE) is a dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine

Glycylsarcosine

Copy Product Info
Synonyms GLYCYL-SARCOSINE

Glycylsarcosine (GLYCYL-SARCOSINE) is a dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine

Glycylsarcosine
Cas No. 29816-01-1

Batch Information
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Purity:98.47%
Appearance:solid
Color:White
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COA HPLC HNMR

Product Introduction
Glycylsarcosine AI Summary
Glycylsarcosine exhibits significant bioactivity related to its interactions with various transporter proteins, particularly PEPT1 and PEPT2. It acts as a substrate and modulator of these transporters, demonstrating different affinities across cell types and species. The compound shows complete absorption in the human intestine after oral administration, with varying permeabilities in different membrane models, including higher permeability in the 2/4/A1 cell model. It has a Ki value of 830,000 nM for the inhibition of the human intestinal peptide carrier and an EC50 value of 540,000 nM for activation of the human PEPT1 transporter, with a max activation of 101% relative to Gly-Sar. Additionally, the compound exhibits moderate to high permeability across human Caco-2 cells, evidenced by a Papp value of 1.1 x 10^-5 cm/s. Furthermore, it shows uptake and inhibition activities in PEPT1 and PEPT2-expressing cells with varying Km and Ki values, indicating its role in transporter-mediated drug absorption and potential implications in drug interactions..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Glycylsarcosine (GLYCYL-SARCOSINE) is a dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine
SynonymsGLYCYL-SARCOSINE
Chemical Properties
Molecular Weight146.14
FormulaC5H10N2O3
Cas No.29816-01-1
SmilesCN(CC(O)=O)C(=O)CN
Relative Density.1.284g/cm3
SequenceH-Gly-Sar-OH
Sequence ShortGG
Storage & Solubility Information
StorageShipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Slightly soluble