Human LEI (Leukocyte Elastase Inhibitor) Sandwich ELISA Kit E0010308)

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	SERPINB1
Gene ID:	1992
Uniprot ID:	ILEU_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.
Post Translational Modifications
Function	Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.
Protein Name	Leukocyte Elastase Inhibitor Lei Monocyte/Neutrophil Elastase Inhibitor Ei M/Nei Peptidase Inhibitor 2 Pi-2 Serpin B1
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Secreted Cytoplasm Cytolytic Granule Early Endosome
Alternative ELISA Names	Leukocyte Elastase Inhibitor ELISA kit Lei ELISA kit Monocyte/Neutrophil Elastase Inhibitor ELISA kit Ei ELISA kit M/Nei ELISA kit Peptidase Inhibitor 2 ELISA kit Pi-2 ELISA kit Serpin B1 ELISA kit SERPINB1 ELISA kit ELANH2 ELISA kit MNEI ELISA kit PI2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance