Size : 1mg
Synonyms:
| Description | L-α-lysophosphatidylinositol sodium is an endogenous ligand of GPR55 and an endogenous cannabinoid neurotransmitter that is involved in controlling cell survival and tumor progression. |
| Targets & IC50 | murine iPSC cardiomyocytes:778 nM (EC50) |
| In vitro | Concentration‐response studies in murine iPSC cardiomyocytes demonstrated that L-α-lysophosphatidylinositol sodium‐induced DMR activity in a concentration‐dependent manner (EC50 = 778 nM) and that the time course of the DMR response was rapid in onset, reached peak activity at 10 minutes post application and persisted for the duration of the period of measurement (90 minutes). [1] |
| In vivo | Challenging WT hearts with L-α-lysophosphatidylinositol sodium prior to the onset of global ischemia significantly increased infarct size compared to vehicle controls, whereas this was not seen in seen GPR55−/− hearts, confirming an action of L-α-lysophosphatidylinositol sodium at GPR55. L-α-lysophosphatidylinositol sodium increases myocardial infarct size in hearts from wild type, but not GPR55−/−, mouse hearts. [1] |
| Molecular Weight | 594.6 |
| Formula | C25H48NaO12P |
| Cas No. | 796963-91-2 |
| Storage | Store at low temperature,Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (6.73 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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