MeCP2 isoform 2 protein

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	MECP2
Gene ID:	4204
Uniprot ID:	MECP2_HUMAN
Immunogen Region:	436-486
Specificity:	This blocking peptide is recommended for use in combination with MeCP2 isoform 2 antibody, STJ501736
Immunogen:	Synthetic peptide taken within amino acid region 436-486 on Methyl-CpG-binding protein 2 isoform 2 protein.

Tissue Specificity	Present in all adult somatic tissues tested.
Post Translational Modifications	Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.
Function	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Peptide Name	Methyl-Cpg-Binding Protein 2 Mecp-2 Protein Mecp2
Database Links	Reactome: R-HSA-8986944 Reactome: R-HSA-9022534 Reactome: R-HSA-9022535 Reactome: R-HSA-9022537 Reactome: R-HSA-9022538 Reactome: R-HSA-9022692 Reactome: R-HSA-9022699 Reactome: R-HSA-9022702 Reactome: R-HSA-9022707 Reactome: R-HSA-9022927 Reactome: R-HSA-9725371
Cellular Localisation	Nucleus Colocalized With Methyl-Cpg In The Genome Colocalized With Tbl1x To The Heterochromatin Foci
Alternative Peptide Names	Methyl-Cpg-Binding Protein 2 protein Mecp-2 Protein protein Mecp2 protein MECP2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance