Specifications

Product Data
Locus ID	4521
Synonyms	MTH1
Vector	pGFP-C-shLenti
E. coli Selection	Chloramphenicol (34 ug/ml)
Mammalian Cell Selection	Puromycin
Format	Lentiviral plasmids
Components	NUDT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4521). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq	NM_002452, NM_198948, NM_198949, NM_198950, NM_198952, NM_198953, NM_198954, NM_198952.1, NM_002452.1, NM_002452.2, NM_002452.3, NM_198948.1, NM_198949.1, NM_198950.1, NM_198953.1, NM_198954.1, BC014618, BC014618.2, BC051375, BC051375.1, BC040144, BC022818, BC065367, BM927392, NM_001367553, NM_001367554, NM_001367555, NR_160264
UniProt ID	P36639
Summary	Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. provided by RefSeq, Dec 2018
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@clinisciences.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage	Store at -20°C
Shipping	Ambient

Product Manuals

HuSH-29 shRNA Plasmids HuSH pRS Cloning Vector HuSH RNAi Validation Vector HuSH pGFP-V-RS Cloning Vector

FAQs

shRNA (HuSH-29)

SDS

SDS for TL302860

RNAi Resources

Product overview Video shRNA Selection Guide FAQ: shRNA FAQ: siRNA FAQ; miRNA Product Brochure: RNAi QC Data for Lenti shRNA