OCEG01208 | OGR1/GPR68 Cell Lysate Clinisciences

OGR1/GPR68 Cell Lysate (OCEG01208)

Datasheets/Manuals	Printable datasheet for OCEG01208

Product Info
Predicted Species Reactivity	Human
Product Format	Liquid. 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol
Application	WB
Reconstitution and Storage	Shipped at ambient temperature, freeze upon arrival. Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles. Products are stable for one year from purchase when stored properly.
Concentration	0.5 mg/ml
Application Info	For use as a positive control with GPR68 polyclonal antibody (Cat. No. OAEG00956) for Western blot analysis.

Reference	Xu, Y., et al. 'Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.' Nature Cell Biol. 2000: 2, 261-267
Description of Target	OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.