Omeprazole [73590-58-6]
Cat# T0757-100mg
Size : 100mg
Marca : TargetMol
Omeprazole
(Synonyms: Prilosec, Losec, H 16868, Antra) Copy Product Info
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
Cas No. 73590-58-6
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.48%
Appearance:Solid
Color:White to Brown
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). |
| In vitro | Omeprazole transiently alters the kinetic properties of parietal cells in rabbits, leading to premature cell death and expedited growth. By inhibiting H(+)-K(+)-ATPase, omeprazole enhances the clearance of degenerative changes and macrophage-mediated removal of parietal cells, as well as promoting the increase of progenitor cells at the apical ridge. |
| In vivo | Omeprazole diminishes the activation of osteoclasts in vitro, while enhancing the activation of osteoblasts, leading to osteosclerosis-like effects to some extent. In human hepatocellular carcinoma cells, omeprazole induces the transcription of reporter genes through dioxin receptor elements recognized by ligand-activated aryl hydrocarbon receptors. It effectively induces the expression of cytochrome P4501A1 mRNA in primary human hepatocytes, but this induction is not detected in mouse primary hepatocytes. Omeprazole significantly suppresses the basal natural killer (NK) activity in splenocytes (SC) from untreated CD2F1 mice. It exerts rapid and robust effects on various types of cytotoxic lymphocytes, ranging from the inhibition of cytotoxicity to irreversible cellular damage. Furthermore, omeprazole notably inhibits the cytotoxicity of all types of effector cells after 30 minutes of incubation. |
| Synonyms | Prilosec, Losec, H 16868, Antra |
| Molecular Weight | 345.42 |
| Formula | C17H19N3O3S |
| Cas No. | 73590-58-6 |
| Smiles | S(CC1=C(C)C(OC)=C(C)C=N1)(=O)C=2NC=3C(N2)=CC=C(OC)C3 |
| Relative Density. | 1.37 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 20 mg/mL (57.9 mM), Sonication is recommended.  DMSO: 100 mg/mL (289.5 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.58 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||