Oxytocin [50-56-6]
Cat# NB-64-29460-10mg
Size : 10mg
Marca : Neo Biotech
Remove All
Oxytocin
(Synonyms: α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone) Copy Product InfoSynonyms: α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone
Catalog No. T5026 Copy Product Info
Purity: 99.87%
Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering.
Cas No. 50-56-6
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:99.87%
Appearance:Solid
Color:White
Contact us for more batch information
Product Information
Oxytocin AI Summary
Oxytocin exhibits a variety of bioactivities, including high binding affinity to the oxytocin receptor (OTR) and vasopressin receptors in different tissues. It acts as an oxytocin receptor antagonist in rat uterine strips both in vitro and in vivo, showing uterotonic activity with varying potency in the presence and absence of Mg2+, and displaying milk ejection activity. The compound demonstrates vasopressor activity and antidiuretic activity in rat models, affecting urinary volume, and electrolyte excretion. It has an EC50 of 0.4 nM for the oxytocin receptor in human cells and shows a preference for the vasopressin V1a receptor with an EC50 of 0.08 nM compared to higher values for the V2 receptor. Oxytocin also shows agonist activity at human vasopressin and oxytocin receptors, affecting intracellular calcium levels in assays. It demonstrates stability in gastric fluid but lower stability in intestinal fluid, indicating potential challenges in oral bioavailability. Additionally, it exhibits good pharmacokinetic properties such as high binding affinity and short half-life in different species, with no significant adverse effects on liver cells. The compound's multifunctional profile, including potent agonist and antagonist activities, makes it a candidate for further exploration in modulating hormonal pathways related to oxytocin and vasopressin receptors..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
| Description | Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering. |
| Targets & IC50 | CHO cells:24.5 nM (EC50), CHO-K1 cells:2.3 nM (EC50), COS-1 cells:15 nM (EC50) |
| In vitro | METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were measured by Hoechst 33342 stained. RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1] |
| In vivo | METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was administered to a carrageenan-induced rat foot-plantar edema model. RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate at the doses of 50 mg/kg and 70 mg/kg showed significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. Tris(2,4-di-tert-butylphenyl)phosphate significantly reduced the volume of raw paw edema. [2] |
| Synonyms | α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone |
| Molecular Weight | 1007.19 |
| Formula | C43H |