This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul
Synonyms
CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Reference Data
Protein Categories
ADC Targets, Allergies and autoimmune diseases, CD Markers, Intracellular Proteins, Membrane Proteins, Nervous system Diseases
Protein Families
Druggable Genome, Transmembrane
Protein Pathways
Cell adhesion molecules (CAMs), T cell receptor signaling pathway
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