Polyethylenimine branched

Biological Activity

Polyethylenimine branched is a surfactant and a non-viral gene delivery vector rich in positively charged amine groups, which can be used in studies related to drug delivery (especially oligonucleotide delivery), and is also one of the most commonly used reagents in small- to large-scale transfection.

Chemical Information

Molecular Weight	800
CAS Number	25987-06-8
Storage	RT

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yansong Zhang et al. Anal Methods. Branched polyethylenimine-assisted boronic acid functionalized magnetic nanoparticles for highly efficient capture of lincomycin and clindamycin

[2] Eun-Su Ko et al. Cell Commun Signal. 25KDa branched polyethylenimine increases interferon-γ production in natural killer cells via improving translation efficiency

[3] Zhongbin Luo et al. Anal Chem. Branched Polyethylenimine-Modified Upconversion Nanohybrid-Mediated Photoelectrochemical Immunoassay with Synergistic Effect of Dual-Purpose Copper Ions

[4] Anh K Lam et al. ChemMedChem. Cationic Branched Polyethylenimine (BPEI) Disables Antibiotic Resistance in Methicillin-Resistant Staphylococcus epidermidis (MRSE)

[5] Paola Vicennati et al. Curr Med Chem. Polyethylenimine in medicinal chemistry