Size : 50mg
Synonyms:
| Description | PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway, efficiently degrading CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1]. |
| Targets & IC50 | CDK9 42:0.10 μM (DC50), CDK9 55:0.14 μM (DC50) |
| In vitro | PROTAC CDK9 degrader-5 (Compound 15e) at 1μM for a duration of 6 hours reduces the protein levels of MCL2 and competitively degrades CDK9 in MV411 cells [1]. Additionally, administration of PROTAC CDK9 degrader-5 at the same concentration demonstrates a time-dependent decrease in the protein levels of both MCL2 and CDK9, with sustained inhibition observed for up to 24 hours [1]. |
| Molecular Weight | 879.78 |
| Formula | C42H48Cl2N8O9 |
| Cas No. | 2935587-89-4 |
| Smiles | O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCCCCC(=O)N4CCC(NC(=O)C=5C(NC(=O)C6=C(Cl)C=CC=C6Cl)=CNN5)CC4)=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
| Size | Quantity | Unit Price | Amount | Operation |
|---|
