Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Selenomethionine [1464-42-2]

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Cat# NB-64-07638-50mg

Size : 50mg

Marca : Neo Biotech

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Selenomethionine

(Synonyms: Seleno-DL-methionine, DL-Selenomethionine) Copy Product Info

Synonyms: Seleno-DL-methionine, DL-Selenomethionine

Catalog No. T1658 Copy Product Info

Purity: 99.95%

DL-Selenomethionine (Seleno-DL-methionine) is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues.

Cas No. 1464-42-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.95%

Color:White

Product Introduction

Selenomethionine AI Summary

Selenomethionine exhibits a diverse range of bioactivities, demonstrating notable inhibitory effects across several targets. It functions as a modulator of Lamin A splicing with a potency of 631.0 nM and as an inhibitor of Aldehyde Dehydrogenase 1 (ALDH1A1) at 39810.7 nM. It also inhibits Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 50118.7 nM and Histone Lysine Methyltransferase G9a at 17782.8 nM. Additionally, Selenomethionine is an inhibitor of the malarial parasite plastid at 1694.4 nM and shows inhibitory effects against Trypanosoma Brucei at 7943.3 nM. It significantly inhibits Plasmodium falciparum (3D7) proliferation with a potency of 43.2 nM, Plasmodium falciparum (DD2) with potencies of 6.9 nM and 153.4 nM in different assays, and Plasmodium falciparum (HB3) at 27282.4 nM. In terms of antiviral activities, Selenomethionine inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours with an inhibition rate of 9.25%. It also displays inhibition of the SARS-CoV-2 3CL-Pro protease by 9.2% at a 20 µM concentration based on a FRET assay. Additionally, the compound inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours of exposure to 0.01 MOI of the virus, with an observed inhibition percentage of 0.02%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-Selenomethionine (Seleno-DL-methionine) is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues.
Synonyms	Seleno-DL-methionine, DL-Selenomethionine

Chemical Properties

Molecular Weight	196.11
Formula	C₅H₁₁NO₂Se
Cas No.	1464-42-2
Smiles	C(C(O)=O)(CC[Se]C)N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1.96 mg/mL (10 mM, insoluble or slightly soluble)

H2O: 11.9 mg/mL (60.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.0992 mL	25.4959 mL	50.9918 mL	254.9590 mL
5 mM	1.0198 mL	5.0992 mL	10.1984 mL	50.9918 mL
10 mM	0.5099 mL	2.5496 mL	5.0992 mL	25.4959 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.2550 mL	1.2748 mL	2.5496 mL	12.7479 mL
50 mM	0.1020 mL	0.5099 mL	1.0198 mL	5.0992 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

SelenomethionineEndogenousMetaboliteEndogenous MetaboliteAutophagyAminoAcidsandDerivativesAmino Acids and Derivatives

Related Tags: Selenomethionine chemical structure | Selenomethionine formula | Selenomethionine molecular weight