Size : 50mg
Synonyms:
| Description | SGK1-IN-3 (compound 3a) is a potent serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor with an IC50 value of less than 1 μM, SGK1-IN-3 is applied in musculoskeletal research to explore SGK1-mediated signaling pathways and its potential role in osteoarthritis pathogenesis and therapeutic intervention. |
| Targets & IC50 | SGK1:0.6 nM |
| In vitro | In kinase assays, SGK1-IN-3 inhibited SGK1 with an IC50 of 0.6 nM, demonstrating selectivity over related AGC kinases S6K1 and AKT [1]. |
| In vivo | In a rat model of Destabilization of the Medial Meniscus (DMM), oral administration of SGK1-IN-3 resulted in cartilage preservation. The treatment reduced cartilage degradation scores (OARSI scores) and inhibited the expression of catabolic markers within the joint tissue. Pharmacokinetic evaluations indicate that the compound possesses oral bioavailability and metabolic stability in rodent models [1]. |
| Molecular Weight | 531.41 |
| Formula | C23H20Cl2N6O3S |
| Cas No. | 2891696-18-5 |
| Smiles | C(N[C@@H]1CCNC1)(=O)C2=C3C(=NC(=C2)C4=CC=C(NS(=O)(=O)C5=C(Cl)C(Cl)=CC=C5)C=C4)NN=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
| Size | Quantity | Unit Price | Amount | Operation |
|---|
