SOD (Mn) Antibody
Cat# OASE00357
Size : 100ug
Marca : Aviva Systems Biology
Contatta il distributore locale :
Telefono : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for OASE00357 |
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| Predicted Species Reactivity | Human, Rat, Mouse, Bovine, Dog, Chicken, Drosophila, Guinea Pig, Pig, Hamster, Monkey, Rabbit, Sheep, Xenopus, Squirrel, Invertebrate, Sea squirt |
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| Product Format | Liquid. PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | WB, IHC, ICC, IF, IP, ELISA |
| :: | Cellular Localization: Mitochondrion matrix |
| Reconstitution and Storage | Store at -20C. Shipping with Blue Ice or 4C. |
| Immunogen | Recombinant Rat Mn SOD Protein |
| Purification | Protein A Purified |
| Concentration | 1 mg/ml |
| Specificity | Detects ~25kDa. |
| Characterization | 0.5 ug/mL was sufficient for detection of Mn SOD in 20ug of rat brain tissue extract by colorimetric immunoblot analysis using Goat anti-rabbit IgG:AP as the secondary antibody. |
| Dilution | WB (1:5000), IHC (1:100), ICC/IF (1:120); optimal dilutions for assays should be determined by the user. |
| Application Info | WB: 1:5000 ICC/IF: 1:120. |
| Reference | 1.Adachi T., et al. (1992). Clin. Chim. Acta. 212: 89-102. 2.Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180. 3.Furukawa Y., O'Halloran T. (2006). Antioxidants & Redo Signaling. Vol 8, No 5,6. 4.Gao B., et al. (2003). Am J Physiol Lung Cell Mol Physiol 284: L917-L925. 5.Hassan H.M. (1988). Free Radical Biol. Med. 5: 377-385. 6.Kurobe N., et al. (1990) Biomedical Research. 11: 187-194 7.Wispe J.R., et al. (1989) BBA. 994: 30-36. 8.Xiao-Hong Liu., et al. (1993) Brain Research. 625: 29-37. |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Publications | Identification and antioxidant activity of synthetic peptides from phycobiliproteins of Pyropia yezoensis. Int J Mol Med. 42, 789-798 (2018). 29717771 PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells. Exp Ther Med. 19, 849-860 (2020). 32010245 |
| Description |
| Gene Symbol | SOD2 |
|---|---|
| Gene Full Name | superoxide dismutase 2, mitochondrial |
| Alias Symbols | Manganese SOD, IPO B, Mn SOD, SOD2 |
| NCBI Gene Id | 24787 |
| Description of Target | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions,however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1). |
| Uniprot ID | P07895 |
| Protein Accession # | NP_058747.1 |
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What is the species homology for "SOD (Mn) Antibody (OASE00357)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Rat, Mouse, Bovine, Dog, Chicken, Drosophila, Guinea Pig, Pig, Hamster, Monkey, Rabbit, Sheep, Xenopus, Squirrel, Invertebrate, Sea squirt".
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How long will it take to receive "SOD (Mn) Antibody (OASE00357)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "SOD (Mn) Antibody (OASE00357)" provided in?
This item is provided in "Liquid. PBS pH7.4, 50% glycerol, 0.09% sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "SOD (Mn) Antibody (OASE00357)"?
This target may also be called "Manganese SOD, IPO B, Mn SOD, SOD2" in publications.
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What is the shipping cost for "SOD (Mn) Antibody (OASE00357)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
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What is the guarantee for "SOD (Mn) Antibody (OASE00357)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "SOD (Mn) Antibody (OASE00357)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "SOD (Mn) Antibody (OASE00357)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "SOD2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "SOD2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "SOD2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "SOD2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "SOD2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "SOD2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.