Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Subasumstat [1858276-04-6]

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Cat# T8428-5mg

Size : 5mg

Marca : TargetMol

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Subasumstat

(Synonyms: TAK-981) Copy Product Info

Subasumstat (TAK-981), a selective inhibitor of the SUMOylation enzymatic cascade, has potential immune-activating and antineoplastic activities.

Cas No. 1858276-04-6

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:98.22%

Appearance:Solid

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Subasumstat (TAK-981), a selective inhibitor of the SUMOylation enzymatic cascade, has potential immune-activating and antineoplastic activities.
In vitro	Methods: HL-60 cells were treated with TAK-981 (10nM; 100nM) for 24 h, and the levels of SUMO-1 and SUMO-2/3 were detected by Western blot. To characterize the effect of the SUMOylation inhibitor TAK-981 on AML cells, we first monitored its effect on SUMOylation in three AML model cell lines HL-60, U937, and THP-1. Results: TAK-981 significantly reduced the global SUMOylation level mediated by SUMO-1 and SUMO-2/3 at 10 nM concentration and almost completely abolished it at 100 nM concentration. [1]
In vivo	Methods: TAK-981 (15 mg/kg) was injected intravenously into the tumor model mice to detect the anti-tumor activity in vivo. Results: TAK981 significantly inhibited tumor growth. [2]
Synonyms	TAK-981

Chemical Properties

Molecular Weight	578.1
Formula	C₂₅H₂₈ClN₅O₅S₂
Cas No.	1858276-04-6
Smiles	Cc1sc(cc1[C@@H]1NCCc2ccc(Cl)cc12)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1
Relative Density.	1.474 g/cm3 (Predicted)

Storage & Solubility Information

Storage

The compound is unstable in solution. Please use soon Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122.5 mg/mL (211.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7298 mL	8.6490 mL	17.2980 mL	86.4902 mL
5 mM	0.3460 mL	1.7298 mL	3.4596 mL	17.2980 mL
10 mM	0.1730 mL	0.8649 mL	1.7298 mL	8.6490 mL
20 mM	0.0865 mL	0.4325 mL	0.8649 mL	4.3245 mL
50 mM	0.0346 mL	0.1730 mL	0.3460 mL	1.7298 mL
100 mM	0.0173 mL	0.0865 mL	0.1730 mL	0.8649 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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