TETi76 [1451750-73-4]
Cat# T200365-25mg
Size : 25mg
Marca : TargetMol
TETi76
Copy Product InfoTETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.
Cas No. 1451750-73-4
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research. |
| Targets & IC50 | TET3:8.8 μM, TET2:9.4 μM, TET1:1.5 μM |
| Molecular Weight | 216.23 |
| Formula | C10H16O5 |
| Cas No. | 1451750-73-4 |
| Smiles | O=C(OCC)C(=C)CC(O)C(=O)OCC |
| Storage | Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |