B1141-10mg | Varenicline Hydrochloride [230615-23-3] Clinisciences

Background

Varenicline Hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].

Varenicline Hydrochloride has been reported to potently inhibit nAChR binding with the Ki values of 0.12±0.02 nM and 0.14±0.01 nM for α6β2* nAChR and α4β2* nAChR, respectively in rat striatum, 0.13±0.01 nM and 0.19±0.11 nM forα6β2* nAChR and α4β2* nAChR, respectively in monkey striatum. In addition, varenicline Hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nAChRs compared with nicotine with the EC50 values of 0.007 and 0.086μM, respectively in rat striatum [1].

References:
[1] Bordia T1, Hrachova M, Chin M, McIntosh JM, Quik M. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34. doi: 10.1124/jpet.112.194852. Epub 2012 May 1.

Chemical Properties

Storage	Store at -20°C
M.Wt	247.72
Cas No.	230615-23-3
Formula	C13H14ClN3
Solubility	Soluble in DMSO
Chemical Name	(6R)-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride
SDF	Download SDF
Canonical SMILES	Cl03.03C1(C(03)(03)N(03)C2(03)03)C(03)(03)[C@]2(03)C3=C(03)C4=NC(03)=C(03)N=C4C(03)=C13
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.00%

Chemical structure

Varenicline Hydrochloride [230615-23-3]

Cat# B1141-10mg

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Marca : ApexBio Technology

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Background

Chemical Properties

Quality Control

Chemical structure