Vincristine sulfate
Cat# M1892-10mg
Size : 10mg
Marca : AbMole Bioscience
All AbMole products are for research use only, cannot be used for human consumption.
leurocristine, Oncovin
Quality Control & Documentation
Biological Activity
Vincristine (leurocristine, Oncovin), sometimes abbreviated "VCR", is a kind of microtubule function inhibitor. Vincristine sulfate is the salt of an alkaloid from the flowering periwinkle plant (also known as Vinca rosea Linn). Vincristine sulfate induces apoptosis in human lymphoma cells. Vincristine binds to tubulin dimers, inhibiting assembly of microtubule structures. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively.
Chemical Information
Molecular Weight | 923.04 |
Formula | C46H56N4O10.H2SO4 |
CAS Number | 2068-78-2 |
Solubility (25°C) | DMSO 80 mg/mL Water 60 mg/mL |
Storage | -20°C, protect from light, sealed |
References
[1] Jordan MA, et al. Cancer Res. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.