IL7 antibody [M25]
Cat# GTX14050-500ug
Size : 500ug
Marca : Genetex
Contatta il distributore locale :
Telefono : +1 850 650 7790
Host | Mouse |
|---|---|
Clonality | Monoclonal |
Clone Name | M25 |
Isotype | IgG2b |
Application | Activation, Neutralizing/Inhibition |
Reactivity | Human, Mouse |
| Package | 500 μg |
Datasheet File View product citations for antibody GTX14050 on CiteAb
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application | Recommended Dilution |
|---|---|
| Activation | Assay dependent |
| Neutralizing/Inhibition | Assay dependent |
| Note : Activationin vivo IL-7 receptor stimulation (as a complex with IL-7) | |
Not tested in other applications.
Calculated MW
20 kDa. ( Note )
Product Note
The M25 antibody is useful for neutralizing the bioactivity of IL-7 as well as administration of IL-7 cytokine. IL-7 administration as a complex with M25 prolongs IL-7 availability in vivo by decreasing specific and nonspecific consumption.
PROPERTIES
Form
Liquid
Buffer
Filter-sterilized PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human IL-7
Purification
Protein G purified
From tissue culture supernatant
From tissue culture supernatant
Purity
>95% (Determined by SDS-PAGE)
Endotoxin
<0.002EU/μg (Determined by LAL gel clotting assay)
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
IL7,interleukin 7
Cellular Localization
Secreted
Background
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]