Mouse Anti-Human CD95-LE/AF

Cat# 9735-14

Size : 0.5mg

Marca : Southern Biotech

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Telefono : +1 850 650 7790
Mouse Anti-Human CD95-LE/AF
More Information
Clone DX3
Isotype Mouse (C3H/He) IgG2aκ
Isotype Control Mouse IgG2a-LE/AF (HOPC-1)
Specificity Human/Rat CD95
Alternative Names APO-1, Fas, TNFRSF6
Description CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance.
Immunogen Human CD95 transfected L cells
Conjugate LE/AF (Low Endotoxin/Azide Free)
Buffer Formulation Phosphate buffered saline, pH 7.4
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Handle under aseptic conditions
Applications Flow Cytometry – Quality tested 1
Immunohistochemistry-Paraffin Sections – Reported in literature 2,3
ELISA – Reported in literature 4

RRID Number AB_2797090
Gene ID 355 (Human)
246097 (Rat)
Gene ID Symbol FAS (Human)
Fas (Rat)
Gene ID Aliases ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6; Tnfrsf6
UniProt ID P25445 (Human)
Q63199 (Rat)
UniProt Name TNR6_HUMAN (Human)
TNR6_RAT (Rat)

Certificate of Analysis Lookup

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  1. 1. Lanier LL, Chang C, Phillips JH. Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J Immunol. 1994;153:2417-28. (Immunogen, FC)
  2. 2. Jacob T, Ascher E, Hingorani A, Kallakuri S. Glycine prevents the induction of apoptosis attributed to mesenteric ischemia/reperfusion injury in a rat model. Surgery. 2003;134:457-66. (IHC-PS, Rat Reactivity)
  3. 3. Miñambres E, Ballesteros MA, Mayorga M, Marin MJ, Muñoz P, Figols J, et al. Cerebral apoptosis in severe traumatic brain injury patients: an in vitro, in vivo, and postmortem study. J Neurotrauma. 2008;25:581-91. (IHC-PS)
  4. 4. Jodo S, Kobayashi S, Kayagaki N, Ogura N, Feng Y, Amasaki Y, et al. Serum levels of soluble Fas/APO-1 (CD95) and its molecular structure in patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. Clin Exp Immunol. 1997;107:89-95. (ELISA)

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