CD8A Mouse Monoclonal Antibody [Clone ID: RFT-8]

Specifications

Product Data
Clone Name	RFT-8
Applications	FC
Recommended Dilution	Flow Cytometry: 10 µL/10e6 cells.
Reactivities	Human
Host	Mouse
Isotype	IgG1
Clonality	Monoclonal
Specificity	This antibody recognizes CD8.
Formulation	PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: PE-TXRD State: Liquid purified Ig fraction. Label: R-Phycoerythrin-Texas Red
Conjugation	PE-TXRD
Storage	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Gene Name	Homo sapiens CD8a molecule (CD8A), transcript variant 1
Database Link	Entrez Gene 925 Human UniProt ID P01732
Background	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 functions primarily as a coreceptor with MHC Class I-restricted TCR's in antigen recognition. (Ref.1-2)
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data
Protein Families	Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways	Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway