Ataxin 1 antibody
Cat# orb151092-100ug
Size : 100ug
Marca : Biorbyt
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Ataxin 1 antibody
Catalog Number: orb151092
| Catalog Number | orb151092 |
|---|---|
| Category | Antibodies |
| Description | Mouse monoclonal to Ataxin 1 (ATTO-488). Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons.. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | S65-37 |
| Tested applications | ICC, WB |
| Reactivity | Human, Mouse, Rat |
| Isotype | IgG1 |
| Immunogen | Synthetic peptide amino acids 746-761 (RKRRWSAPETRKLEKS) of mouse ataxin-1. Rat: 93% identity (15/16 amino acids identical). Human: 87% identity (14/16 amino acids identical). |
| Concentration | 1 mg/ml |
| Dilution range | WB (1:1000) |
| Conjugation | ATTO-488 |
| MW | 85kDa |
| Target | Ataxin 1 |
| Entrez | 20238 |
| UniProt ID | P54254 |
| NCBI | NP_001186233.1 |
| Storage | Conjugated antibodies should be stored at 4°C |
| Buffer/Preservatives | PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated |
| Alternative names | Ataxin-1 antibody, ATX1 antibody, Atxn1 antibody, |
| Note | For research use only |
| Application notes | 1 µg/ml of SMC-475 was sufficient for detection of Ataxin 1 in 20 µg of COS cells transiently transfected with Ataxin-1 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Expiration Date | 12 months from date of receipt. |