α-Thujone [546-80-5]

Cat# orb1299134-10mg

Size : 10mg

Marca : Biorbyt


α-Thujone

SKU: orb1299134

Description

α-Thujone is a small molecule inhibitor of acetylcholinesterase (AChE) with an IC50 of 24.7 µM. It is used in neuroscience research to study cholinergic signaling and has been investigated in vitro for its neuroactive properties.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number546-80-5
MW152.23
Purity97.02% (May vary between batches)
FormulaC10H16O
SMILES20[C@]12C[C@]1(CC(=O)[C@@H]2C)C(C)C
TargetAChR,Autophagy,ROS,GABA Receptor,Reactive Oxygen Species,Parasite,Apoptosis
SolubilityDMSO:4.4 mg/mL (28.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.57 mM)

Bioactivity

Target IC50
α7 nAChR:24.7μM
In Vitro
In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, a-Thujone, Autophagy, anthelmintic, antinociceptive, anti-invasive, anti-tumor, ALPHA-(-)-THUJONE, ALPHA-THUJONE, BBB, AChR, GABAReceptor, GABA Receptor, GABAA, Gamma-aminobutyric acid Receptor, insecticidal, Parasite, Inhibitor, inhibit, Monoterpene, α Thujone, αThujone, α-Thujone, γ-Aminobutyric acid Receptor, ROS, stress, oxidative, Thujone, ReactiveOxygenSpecies, Reactive Oxygen Species, pro-apoptotic

Key Properties

No computed properties available.

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α-Thujone (orb1299134)

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