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> Anti-YAP1 Antibody (3O376)

Anti-YAP1 Antibody (3O376)

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Cat# NB-64-119651-100uL

Size : 100uL

Marca : Neo Biotech


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Anti-YAP1 Antibody (3O376)

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Catalog No. TMAC-04307 Copy Product Info
Anti-YAP1 Antibody (3O376) is a Mouse antibody targeting YAP1. Anti-YAP1 Antibody (3O376) can be used in IF,IP,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-YAP1 Antibody (3O376) is a Mouse antibody targeting YAP1. Anti-YAP1 Antibody (3O376) can be used in IF,IP,WB.
Clone
3O376
Reactivity
Human,Mouse,Rat
Verified Activity
1. Western blot analysis of YAP expression in non-transfected 293T (A), human YAP transfected 293T (B) and Caco-2 (C) whole cell lysates.
Anti-YAP1 Antibody (3O376)
Application
IF
IP
WB
Recommended Dose
WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe Yes-associated protein, otherwise known as YAP, is a 14-3-3-bindingmolecule that was originally recognized by virtue of its ability to bind to theSH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylationof a homologous serine residue (Ser 112) in the YAP 14-3-3-binding motif. Thehighly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation,cell cycle progression and apoptosis by binding intracellular phosphoproteinsinvolved in signal transduction. YAP may link events at the plasmamembrane and cytoskeleton to inhibition of transcription in the nucleus in amanner regulated by 14-3-3 proteins. YAP shares homology with the WWdomain of TAZ, transcriptional co-activator with PDZ-binding motif, whichfunctions as a transcriptional co-activator by binding to the PPXY motif presentin transcription factors. YAP is expressed at high levels in the lung, placenta,prostate, ovary and testis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Amino acids 294-323 within an internal region of YAP of human origin
Antigen Species
Human
Uniprot ID
P46937
Chemical Properties
Molecular WeightTheoretical: 65 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze.
TransportShipping with blue ice.

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Keywords

Yes-associated protein YAP65 homologYes-associated protein 1YAP65YAP1YAP 65YAP 1Transcriptional coactivator YAP1Protein yorkie homolog
Related Tags: Anti-YAP1 Antibody (3O376) molecular weight