Orb1226943-200mg | Baclofen [1134-47-0] Clinisciences

Baclofen

SKU: orb1226943

Description

A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist; also blocks α2δ subunit-containing voltage-dependent calcium channel (VDCC) with Ki of 156 uM; A neurotransmitter inhibitor by blocking the release of excitatory transmitters; serves as a central nervous system depressant and skeletal muscle relaxant.Other Indication Approved(In Vitro):Baclofen (1, 10 μM; 24 h) causes markedly decreased lactate dehydrogenase (LDH) activity, indicating increased cell viability in wild-type or mutant huntingtin-expressing striatal cells (HD19 or HD43). Baclofen significantly increases chymotrypsin-like proteasome activity and cell viability were in the HD43 cells.(In Vivo):Baclofen (i.p.; 10 μg/g; twice daily for 3 consecutive days) ameliorates motor deficits in YAC128 HD transgenic mice.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1134-47-0
MW	213.6608
Purity	>98% (HPLC)
Formula	C₁₀H₁₂ClNO₂
SMILES	O=C(O)CC(C1=CC=C(Cl)C=C1)CN
Target	GAT
Solubility	DMSO: < 7.8 mg/mL

Bioactivity

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In Vivo	Animal model: Wild type (WT) and mutant (MT) male YAC128 mice at 13-18 months of age. Dosage: 10 μg/g. Administration: IP; twice daily at 9: 00 a. m. and 5: 00 p. m. , for 3 consecutive days; then single dose on the fourth day at 9: 00 a. m. Result: Ameliorated motor deficits in YAC128 HD transgenic mice. Increased proteasome activity and reduces neuronal intranuclear inclusions (NIIs) in YAC128 HD transgenic mice.

In Vivo

Animal model: Wild type (WT) and mutant (MT) male YAC128 mice at 13-18 months of age. Dosage: 10 μg/g. Administration: IP; twice daily at 9: 00 a. m. and 5: 00 p. m. , for 3 consecutive days; then single dose on the fourth day at 9: 00 a. m. Result: Ameliorated motor deficits in YAC128 HD transgenic mice. Increased proteasome activity and reduces neuronal intranuclear inclusions (NIIs) in YAC128 HD transgenic mice.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Baclofen | Lioresal, Liofen, Gablofen | Baclon | Kemstro

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(R)-baclofen [orb1300840]
Purity:
99.43% (May vary between batches)
CAS Number:
69308-37-8
MW:
213.66
Formula:
C₁₀H₁₂ClNO₂
Sizes Available: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg
Arbaclofen placarbil [orb1698352]
CAS Number:
847353-30-4
MW:
399.87
Formula:
C₁₉H₂₆ClNO₆
Sizes Available: 100 mg, 50 mg, 25 mg
(R)-Baclofen hydrochloride [orb1706430]
CAS Number:
63701-55-3
MW:
250.12
Formula:
C₁₀H₁₃Cl₂NO₂
Sizes Available: 100 mg, 250 mg, 1 g
(S)-Baclofen [orb1705303]
CAS Number:
66514-99-6
MW:
213.66
Formula:
C₁₀H₁₂ClNO₂
Sizes Available: 25 mg, 50 mg, 100 mg
Phaclofen [orb1704235]
Purity:
99.32% (May vary between batches)
CAS Number:
114012-12-3
MW:
249.63
Formula:
C₉H₁₃ClNO₃P
Sizes Available: 5 mg, 50 mg, 100 mg, 1 mg, 25 mg, 10 mg, 200 mg

Quick Database Links

Gene Symbol

GAT

Baclofen [1134-47-0]

Cat# orb1226943-200mg

Marca : Biorbyt

Baclofen

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

(R)-baclofen [orb1300840]

Arbaclofen placarbil [orb1698352]

(R)-Baclofen hydrochloride [orb1706430]

(S)-Baclofen [orb1705303]

Phaclofen [orb1704235]

Quick Database Links

Protocol Information

Purity:	99.43% (May vary between batches)
CAS Number:	69308-37-8
MW:	213.66
Formula:	C₁₀H₁₂ClNO₂

CAS Number:	847353-30-4
MW:	399.87
Formula:	C₁₉H₂₆ClNO₆

CAS Number:	63701-55-3
MW:	250.12
Formula:	C₁₀H₁₃Cl₂NO₂

Purity:	99.32% (May vary between batches)
CAS Number:	114012-12-3
MW:	249.63
Formula:	C₉H₁₃ClNO₃P