CD81 Antibody
Cat# OAEE00980
Size : 100tests(T100)
Marca : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for CD81 Antibody |
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| Predicted Species Reactivity | Cat|Human|Rabbit |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | M38 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | FITC |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | MOLT-4 (human T-ALL cell line) |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 20 ul / test |
| Specificity | The antibody M38 reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells. |
| Formulation | FITC |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Stehlíková O, Chovancová J, Tichý B, Krejčí M, Brychtová Y, Panovská A, Francová Skuhrová H, Burčková K, Borský M, Loja T, Mayer J, Pospíšilová S, Doubek M: Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice. Int J Lab Hematol. 2013 Sep 13. doi: 10.1111/ijlh.12149. Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O: Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. J Virol. 1992 Mar;66(3):1394-401. Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ: Selective enrichment of tetraspan proteins on the internal vesicles ofmultivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998 Aug 7;273(32):20121-7." Imai T, Kakizaki M, Nishimura M, Yoshie O: Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J Immunol. 1995 Aug 1;155(3):1229-39. Imai T, Yoshie O: C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. J Immunol. 1993 Dec 1;151(11):6470-81. |
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| Gene Symbol | CD81 |
| Gene Full Name | CD81 molecule |
| Alias Symbols | 26 kDa cell surface protein TAPA-1, CD81 antigen, CD81 antigen (target of antiproliferative antibody 1), CVID6, S5.7, TAPA1, Target of the antiproliferative antibody 1, tetraspanin-28, tspan-28, TSPAN28. |
| NCBI Gene Id | 975 |
| Protein Name | CD81 antigen |
| Description of Target | May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. |
| Uniprot ID | P60033 |
| Protein Accession # | NP_001284578.1; NP_004347.1 |
| Nucleotide Accession # | NM_001297649.1; NM_004356.3 |
